27 Apr Bio-Me’s technology used for identifying bacteria associated with appendicular lean mass in a Nature Communications publication

PMP™, Bio-Me´s microbiome analysis platform, was used to identify three gut bacterial species that are directly associated with appendicular lean mass and bone mineral density.

OSLO, Norway, April 27, 2023 – A recent study published in Nature Communications investigated the associations between prevalent gut microbes and appendicular lean mas (ALM). A total of 5196 fecal samples from the population-wide HUNT Biobank in Norway were analyzed with Bio-Me’s Precision Microbiome Profiling (PMP™) platform for determining the absolute quantification of 50 prevalent and well-characterized gut microbes.

The study identified three anabolic gut bacterial species (Coprococcus comes, Dorea longicatena, and Eubacterium ventriosum) that are directly associated with ALM and bone mineral density when combined into an anabolic species count.

Previous human studies have shown inconsistent results when testing for associations between the gut microbiome and lean mass; this may be caused by the small sample size. In addition, most studies used 16S rRNA sequencing, which does not provide detailed species-level information. This study overcomes these problems due to its large sample size and species-level resolution.

Morten Isaksen, Chief Innovation Officer of Bio-Me, comments: This is the largest study to date investigating the role of the gut microbiome on ALM and BMD. Our rapid and high-throughput PMP™ platform is ideal for large-scale cohort studies like this. We are thrilled to see that our targeted approach can be useful also in discovery research.

Link to the publication: https://www.nature.com/articles/s41467-023-37978-9